{"product_id":"adaptive-design-methods-in-clinical-trials-paperback","title":"Adaptive Design Methods in Clinical Trials - Paperback","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eShein-Chung Chow\u003c\/b\u003e (Author), \u003cb\u003eMark Chang\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eWith new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. \u003cstrong\u003eAdaptive Design Methods in Clinical Trials, Second Edition\u003c\/strong\u003e reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003e\u003cstrong\u003eNew to the Second Edition\u003c\/strong\u003e\u003c\/em\u003eAlong with revisions throughout the text, this edition significantly updates the chapters on protocol amendment and clinical trial simulation to incorporate the latest changes. It also includes five entirely new chapters on two-stage adaptive design, biomarker adaptive trials, target clinical trials, sample size and power estimation, and regulatory perspectives.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFollowing in the tradition of its acclaimed predecessor, this second edition continues to offer an up-to-date resource for clinical scientists and researchers in academia, regulatory agencies, and the pharmaceutical industry. Written in an intuitive style at a basic mathematical and statistical level, the book maintains its practical approach with an emphasis on concepts via numerous examples and illustrations. \u003c\/p\u003e\u003ch3\u003eAuthor Biography\u003c\/h3\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eShein-Chung Chow\u003c\/strong\u003e is a professor in the Department of Biostatistics and Bioinformatics at Duke University School of Medicine. Dr. Chow is also an adjunct professor of clinical sciences at Duke-National University of Singapore Graduate Medical School and the editor-in-chief of the \u003cem\u003eJournal of Biopharmaceutical Statistics\u003c\/em\u003e. He has authored or co-authored numerous papers and books, including the \u003cem\u003eHandbook of Adaptive Designs in Pharmaceutical and Clinical Development \u003c\/em\u003eand \u003cem\u003eControversial Statistical Issues in Clinical Trials\u003c\/em\u003e.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMark Chang\u003c\/strong\u003e is the executive director of biostatistics and data management at AMAG Pharmaceuticals and an adjunct professor at Boston University. A fellow of the American Statistical Association, Dr. Chang is a co-founder of the International Society for Biopharmaceutical Statistics and serves on the editorial boards of two statistical journals. He has authored many publications, including \u003cem\u003eAdaptive Design Theory and Implementation Using SAS and R \u003c\/em\u003eand\u003cem\u003e Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies\u003c\/em\u003e.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 374\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.78 x 9.21 x 6.14 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eIllustrated:\u003c\/strong\u003e Yes\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e January 21, 2023\u003c\/div\u003e\n            ","brand":"Books by splitShops","offers":[{"title":"Default Title","offer_id":47371560452274,"sku":"9781032477602","price":107.97,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0770\/3891\/1666\/files\/WnxyFhnu7m9781032477602.webp?v=1782969032","url":"https:\/\/box.dadyminds.org\/products\/adaptive-design-methods-in-clinical-trials-paperback","provider":"DADYMINDS BOX","version":"1.0","type":"link"}