{"product_id":"the-biology-of-the-tgf-946-family-hardcover","title":"The Biology of the Tgf-\u0026#946; Family - Hardcover","description":"\u003cp\u003eby \u003cb\u003eRik Derynck\u003c\/b\u003e (Author), \u003cb\u003eKohei Miyazono\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003eThe transforming growth factor (TGF-) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. The TGF- family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. TGF- signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Biology\u003c\/em\u003e provides a comprehensive view of the different members of the TGF- family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF- family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed, as is cross talk between TGF- and other signaling pathways (e.g., Wnt). Individual chapters are devoted to the roles of TGF- signaling in specific biological processes, including cell proliferation, mesenchymal differentiation, branching morphogenesis, stem cell biology, immunity, vascular function, reproduction, and neurobiology. The roles of TGF- signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered. \u003cp\u003e\u003c\/p\u003eThe authors also review TGF- signaling in model organisms (e.g., C. elegans and Drosophila), as well as the discovery of TGF- and early research in the field. This volume is therefore a comprehensive reference on the biology of the TGF- family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research.\u003cbr\u003e\u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 1164\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 2 x 10.2 x 7.4 IN\u003c\/div\u003e\u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e July 31, 2017\u003c\/div\u003e","brand":"Books by splitShops","offers":[{"title":"Default Title","offer_id":47482738802866,"sku":"9781621820369","price":57.71,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0770\/3891\/1666\/files\/121178870203a07de2759ad195570c87.webp?v=1779264950","url":"https:\/\/box.dadyminds.org\/products\/the-biology-of-the-tgf-946-family-hardcover","provider":"DADYMINDS BOX","version":"1.0","type":"link"}